HERBAL MEDICINE

A traditional Chinese herbal medicine consisting of five herbs may benefit people with eczema, new research in the British Journal of Dermatology will reveal.

Scientists at the Chinese University of Hong Kong evaluated the effects of ‘pentaherbs formulation’ on patients aged between five and 21 with atopic eczema, the most common type of the disease which affects at least one in ten children.

The pentaherbs formulation capsules contain extracts of five raw herbs based on a widely used ancestral Chinese concoction – Flos lonicerae (Japanese honeysuckle), Herba menthae (peppermint), Cortex moutan (root bark of peony tree), Atractylodes Rhizome (underground stem of the atractylodes herb) and Cortex phellodendri (Amur cork-tree bark).

The first study was a clinical trial of 85 patient divided into a control group receiving a placebo, and a group taking the pentaherbs formulation. Using a questionnaire index that measures how much a skin problem affects a patient, the scientists found that the quality of life improved by a third in the group taking the herbs, compared to no improvement in the placebo-treated group.

The researchers also found that the herbal remedy reduced patients’ needs for the conventional treatment of topical steroids, with the duration of use reduced by an average of four days per month in the herbal group, compared to one day per month in the placebo group. read more »

In today’s age many people are looking to herbal remedies as a natural and alternative form of medication to relieve illnesses and maintain good health, but various EU guidelines make it very difficult to register a traditional herbal medicinal product (THMP) in Europe.

The Royal Pharmaceutical Society of Great Britain (RPSGB) will host a masterclass providing practical advice on registering a THMP on Friday 13 November 2009 at the RPSGB London headquarters.

Bringing together a host of professionals within the herbal medicines sector and the regulators at the health authority, the event will aim to provide advice on a practical level to those registering a THMP and share to delegates the experience of the UK MHRA in the assessment of applications. The programme is designed by the authors of ‘A Practical Guide to Licensing Herbal Medicinal Products – a recently launched PhP publication’. read more »

A well-known Eastern medicine supplement may help avoid the most common cause of liver transplantation, according to a study by researchers at the Stanford University School of Medicine. The finding came as a surprise to the scientists, who used a number of advanced genetic and genomic techniques in mice to identify a molecular pathway that counters acetaminophen toxicity, which leads to liver failure.

“I didn’t know anything about the substance that was necessary for the pathway’s function, so I had to look it up,” said Gary Peltz, MD, PhD, professor of anesthesiology. “My postdoctoral fellow, whose parents and other family members in Asia were taking this compound in their supplements, started laughing. He recognized it immediately.”

The molecule was S-methylmethionine, which had been marketed as an herbal medicine known as Vitamin U for treatment of the digestive system. It is highly abundant in many plants, including cabbage and wheat, and is routinely ingested by people. Coincidentally, Garnett Cheney, MD, at Stanford University performed a series of studies in the 1950s in which he used the compound to treat peptic ulcers.

Peltz is the senior author of the research, which will be published online Nov. 18 in Genome Research. The experiments were conducted in Peltz’s laboratory at Roche Palo Alto in Palo Alto, Calif., where Peltz worked before coming to Stanford in July 2008. He is continuing the research at Stanford. The first author of the paper, Hong-Hsing Liu, MD, PhD, is now a postdoctoral scholar in Peltz’s Stanford lab.

Acetaminophen is a pain reliever present in many over-the-counter cold and flu medicines. It is broken down, or metabolized, in the body into byproducts – one of which can be very toxic to the liver. At normal, therapeutic levels, this byproduct is easily deactivated when it binds to a naturally occurring, protective molecule called glutathione. But the body’s glutathione stores are finite, and are quickly depleted when the recommended doses of acetaminophen are exceeded.

Unfortunately, the prevalence of acetaminophen makes it easy to accidentally exceed the recommended levels, which can occur by dosing more frequently than indicated or by combining two or more acetaminophen-containing products. However, severe liver damage can occur at even two to three times the recommended dose (the maximum adult dose is 4 grams per day; toxic daily levels range from 7 to 10 grams). read more »